Synthesis of Eurystatin A

Structure of Eurystatin A

C23H38N4O5

Principal investigatorJ. Edward Semple
Publication year2001
Synthesis typeTotal
Number of steps 9 (linear)
References
Part 1 of 1
intermediate structure
CH3CO2CHO
Et3N
0 °C to RT, , 90%
intermediate structure
ClCO2CCl3, N-Methylmorpholine
CH2Cl2
-40 to -15 °C, , 98%
intermediate structure + intermediate structure + intermediate structure
CH2Cl2
0 °C to RT, 4 d, 80%
intermediate structure
Et2NH
CH2Cl2
RT, ON, 75%
intermediate structure
H2, Pd/C
MeOH
95%
intermediate structure
(PhO)2P(O)N3, NaHCO3
DMF
0-4 °C, 5 d, 85%
intermediate structure
HCl
EtOAc
0 °C to RT, , 100%
intermediate structure + intermediate structure
EDC, HOAt
DMF
RT, , 93%
intermediate structure
DMSO, Et3N, Pyr.SO3
CH2Cl2
5 °C to RT, , 75%
intermediate structure