Synthesis of Dibromophakellstatin

C11H10Br2N4O2
Principal investigator | David J. Austin |
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Publication year | 2004 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
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CH2Cl2
RT, ON, 49%


MsCl,
DBU
CH2Cl2
0 °C to RT, ON, 67% (2 steps)

TMSN3,
n-Bu4N+ I-,
PhI(OAc)2
CH2Cl2
-30 °C to RT, ON, 41%
"Also isolated was the C10-epimer (7 % yield)."

Pd/C,
H2
1 atm
MeOH
RT, ON, 75%

TCDI,
Imidazole
MeCN
50 °C, 69%

NH3,
H2O2
DMF, H2O
RT, 4 h, 91%

NBS
THF
RT, ON, 30%
