Synthesis of Marasmic Acid
C15H18O4
| Principal investigator | Robert B. Woodward |
|---|---|
| Publication year | 1976 |
| Synthesis type | Total |
| Number of steps | 8 (linear) |
| References |
Part 1 of 1
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TsOH,
Isobutylene
CH2Cl2
RT, 4 d
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KOt-Bu
PhH, t-BuOH
RT, 10 min, 44% (3 steps)
i-Bu2AlH
PhMe
-78 °C, 4 h
NaBH4
MeOH
RT, 15 min, 65% (2 steps)
Phosgene,
Quinoline
Et2O
0 °C, 45 min, 91%
Et3N
DMSO
15 °C, 45 min, 25%
CF3CO2H
PhH
RT, 30 min, 50%