Synthesis of Epilupinine
C10H19NO
| Principal investigator | Frederick G. West |
|---|---|
| Publication year | 1994 |
| Synthesis type | Total |
| Number of steps | 5 (linear) |
| References |
Part 1 of 1
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Et3N
EtOAc
60 °C, ON, 80%
Cu(acac)2
PhMe
Reflux, 2.5 h, 82%
See the Stevens Rearrangement
"The product is a 95:5 mixture of diastereomers at C-5 (major shown).
88:12 e.r."
BF3.OEt2,
(CH2SH)2
RT, 48 h, 64%
LiAlH4
THF
0 °C to RT, 3 h, 94%