Synthesis of Epilupinine

C10H19NO
Principal investigator | Frederick G. West |
---|---|
Publication year | 1994 |
Synthesis type | Total |
Number of steps | 5 (linear) |
References |
Part 1 of 1
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Et3N
EtOAc
60 °C, ON, 80%

Cu(acac)2
PhMe
Reflux, 2.5 h, 82%
See the Stevens Rearrangement
"The product is a 95:5 mixture of diastereomers at C-5 (major shown).
88:12 e.r."

BF3.OEt2,
(CH2SH)2
RT, 48 h, 64%

LiAlH4
THF
0 °C to RT, 3 h, 94%

