Synthesis of Clostrubin

C25H18O6
Principal investigator | Ang Li |
---|---|
Publication year | 2015 |
Synthesis type | Total |
Number of steps | 13 (3 parts) |
References |
Part 1 of 3
+




HCl,
SnCl2.2H2O
AcOH, H2O
RT, 30 min

DBU,
TsN3
CH2Cl2
RT, 20 h, 89% (2 steps)

Part 2 of 3






NaOMe
MeOH
RT to 50 °C, 4 h, 66%

Part 3 of 3
+



hv
CHCl3
RT, 8 h, 55%

HBr
AcOH, H2O
120 °C, 10 h, 95%
