Synthesis of Mycophenolic Acid

C17H20O6
Principal investigator | Rick L. Danheiser |
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Publication year | 1986 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
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NaBH4
EtOH
0 °C to RT, 30 min

DMAP,
Et3N,
TBSCl
CH2Cl2
RT, 20 h

K2CO3
MeOH
RT, 24 h, 83% (2 steps)


- MsCl , n-BuLi
- Li2CuCl4
THF
-78 °C to RT, 8 h, 91%



t-BuNH2,
Br2
PhMe
-78 to 5 °C, 4 h, 85%

- MeLi.LiBr
- t-BuLi
- CO2
THF
-78 to 0 °C, 2.5 h

HCl
H2O, MeOH
Reflux, 4.5 h, 70% (2 steps)

