Synthesis of Clavukerin A

C12H18
Principal investigator | Hans J. Schäfer |
---|---|
Publication year | 2002 |
Synthesis type | Formal |
Number of steps | 7 (linear) |
References |
Part 1 of 1
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CuCN,
MeLi
Et2O
-78 °C, 81%



TiCl4
CH2Cl2
-78 °C, 60 min, 46%
See the Danheiser Annulation
"Also isolated was the C8-epimer (46 % yield)."

K2CO3
MeOH
RT, 2 h

n-Bu4N+ F-
MeOH
78% (2 steps)

Remaining...
73% (2 steps)
"See : J. Org. Chem. 1991, 56, 6829."
