Synthesis of Aflatoxin B2

Structure of Aflatoxin B2

C17H14O6

Principal investigatorElias J. Corey
Publication year2005
Synthesis typeTotal
Number of steps 8 (linear)
References
Part 1 of 1
intermediate structure + intermediate structure
MeCN
RT, 5 h, 65%
"The product was cristallized to optical purity."
intermediate structure
HMTA
AcOH
110 °C, 48 h, 40%
See the Duff Reaction
intermediate structure
DMAP, Tf2O
CH2Cl2, Pyr
-20 to 0 °C, 2 h, 80%
intermediate structure
MeMgBr
THF
-20 °C, 2 h
intermediate structure
Dess-Martin Periodinane
CH2Cl2
0 °C to RT, 3 h, 85% (2 steps)
intermediate structure
H2O2 (Urea complex), (CF3CO)2O
CH2Cl2
RT, 45 h, 63%
intermediate structure
H2, Ni (Raney)
MeOH
RT, 3 h, 60%
intermediate structure + intermediate structure
NaHCO3, ZnCO3
CH2Cl2
RT, 20 h, 36%
intermediate structure