Synthesis of Methoxatin

C14H6N2O8
Principal investigator | Charles W. Rees |
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Publication year | 1983 |
Synthesis type | Total |
Number of steps | 11 (linear) |
References |
Part 1 of 1
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BnBr,
K2CO3
Acetone
Reflux, 24 h, 92%

LiAlH4
THF
0 °C, 2 h, 83%

BaMnO4
CHCl3
Reflux, 60 min, 100%




HCl
MeOH
Reflux, 6 h, 58%



Pd/C,
H2
1 atm
MeOH
RT, 20 h, 89%


CHCl3, MeOH
RT, 16 h, 93%

TsOH,
HC(OMe)3
MeOH
Reflux, 3 h

HCl,
K2CO3
H2O
85 °C, 4 h, 79% (2 steps)
