Synthesis of Aflatoxin B1

Structure of Aflatoxin B1

C17H12O6

Principal investigatorBarry M. Trost
Publication year2003
Synthesis typeTotal
Number of steps 9 (linear)
References
Part 1 of 1
intermediate structure + intermediate structure
HCl
EtOH
RT, 72 h, 47%
intermediate structure
ICl
CH2Cl2
RT, 30 min, 92%
intermediate structure + intermediate structure
Pd2(dba)3.CHCl3, n-Bu4N+ Cl-
CH2Cl2
RT, 12 h, 89%
intermediate structure
HCO2H, PdCl2.2MeCN
DMF, Et3N
60 °C, 60 min, 93%
See the Heck Coupling
intermediate structure
HCl
AcOH, H2O
RT, 48 h
intermediate structure
LiClO4, Sc(OTf)3
MeNO2
60 °C, 4 h, 32% (2 steps)
intermediate structure
i-Bu2AlH
CH2Cl2
-78 °C, 60 min, 57%
intermediate structure
Ac2O
AcOH
RT, 20 h
intermediate structure
PhMe
240 °C, 15 min, 24% (2 steps)
intermediate structure