Synthesis of Nupharamine

Structure of Nupharamine

C15H25NO2

Principal investigatorJerzy T. Wróbel
Publication year1977
Synthesis typeTotal
Number of steps 7 (linear)
References
Part 1 of 1
intermediate structure
Na, HCO2Et
Et2O
100%
intermediate structure + intermediate structure
AcOH
PhH
RT, 60 min, 35%
intermediate structure
LiAlH4
Et2O
Reflux, 3 h, 100%
intermediate structure
HBr, Zn
AcOH, H2O
RT to Reflux, 50 min, 63%
intermediate structure + intermediate structure
NaNH2
Et2O, NH3
-50 to -33 °C, 15 min, 45%
intermediate structure
Na
EtOH, Xylene(s)
Reflux, , 12%
intermediate structure
HCO2H, HClO4
H2O, MeOH
RT, 40 h, 5%
intermediate structure