Synthesis of Daphnilactone A

C23H35NO2
Principal investigator | Clayton H. Heathcock |
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Publication year | 1989 |
Synthesis type | Total |
Number of steps | 12 (2 parts) |
References |
Part 1 of 2
Part 2 of 2
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i-Pr2NLi
THF
-78 to 0 °C, 4 h, 85%

LiAlH4
Et2O
0 °C to RT, 60 min, 96%


Pyr
CH2Cl2
0 °C, 10 min, 95%


LiAlH4
Et2O
RT, 6 h, 90%



PtO2,
H2
1 atm
EtOH
RT, 60 min, 99%



