Synthesis of Colchicine

C22H25NO6
Principal investigator | David A. Evans |
---|---|
Publication year | 1981 |
Synthesis type | Formal |
Number of steps | 12 (linear) |
References |
Part 1 of 1
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Pt (Anode),
KOH
4.0 V
MeOH
0 °C, 25 h

(CO2H)2
H2O, THF
RT, 12 h, 65% (2 steps)




(CO2H)2
H2O, THF
RT, 5 h, 95% (2 steps)
"Mixture of isomers."

CF3CO2H
Reflux, 35 min, 92%

DDQ
PhH
Reflux, 18 h, 54%

NaOMe
H2O, MeOH
75 °C, 45 min, 85%


HCl
H2O
110 °C, 90 min, 72%

Remaining...
(2 steps)
"See : Helv. Chim. Acta 1957, 40, 193; Helv. Chim. Acta 1946, 29, 246."
