Synthesis of Julifloridine

Structure of Julifloridine

C18H37NO2

Principal investigator	André B. Charette
Publication year	2005
Synthesis type	Total
Number of steps	4 (linear)
References	Org. Lett. 2005, 7, 2747.

Part 1 of 1

intermediate structure

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intermediate structure

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intermediate structure

LiI, Tf2O

CH2Cl2

-78 °C to RT, 16 h, 80%

intermediate structure

H2, Pd/C

1 atm

PhMe

RT, 2 h, 71%

intermediate structure

DMDO
Me2Zn

Acetone, THF

-78 °C, 15 h, 73%

intermediate structure

Li

EtOH, NH3, THF

-33 °C, 3.5 h, 83%

See the Birch Reduction

intermediate structure

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