Synthesis of Twistane

C10H16
Principal investigator | Pierre Deslongchamps |
---|---|
Publication year | 1967 |
Synthesis type | Total |
Number of steps | 7 (linear) |
References |
Part 1 of 1

TsOH,
HC(OEt)3
EtOH
-20 to 0 °C, 60 min, 65%

Li
EtOH, NH3, THF
-33 °C, 60 min, 99%

Pyr,
MsCl
CH2Cl2
-10 °C, 24 h

(CO2H)2
Et2O, H2O
RT, 2 h, 59% (2 steps)

NaH
Dioxane
Reflux, 5 h, 85%

(CH2SH)2,
BF3.OEt2
AcOH
RT, 16 h, 100%

Ni (Raney)
EtOH
Reflux, 5 h, 70%
