Synthesis of Quinine

C20H24N2O2
Principal investigator | Paul Rabe |
---|---|
Publication year | 1918 |
Synthesis type | Partial |
Number of steps | 3 (linear) |
References |
Part 1 of 1

HCl,
NaOBr
Et2O, H2O
RT, 24 h, 55%
"The starting material (quinotoxine) was obtained from the degradation of natural quinine."


Al,
NaOEt
EtOH
Reflux, 2 h, 5%
"(-)-Quinine was selectively cristallized (as a tartrate salt) from the resulting four diastereoisomers."
