Steglich Esterification

Schematic representation of the Steglich Esterification.

Mechanism of the Steglich Esterification

Mechanism of the Steglich Esterification

Original publication	Angew. Chem. Int. Ed.. 1978, 17, 522.
Review

Sample reactions

intermediate structure

DCC, Cl3CCH2OH

CH2Cl2, Pyr

intermediate structure

intermediate structure

DCC

Pyr

100 °C, 2 h, 67%

intermediate structure

intermediate structure

intermediate structure

DCC, DMAP

CH2Cl2

36 h, 82%

intermediate structure

intermediate structure

intermediate structure

DCC, DMAP

CH2Cl2

-20 °C, 20 h, 98%

intermediate structure

intermediate structure

intermediate structure

DCC, DMAP

CH2Cl2

RT, 40 h, 86%

intermediate structure

intermediate structure

DMAP, ClCH2CO2H, DIC

CH2Cl2

0 °C to RT, 60 min, 73% (3 steps)

intermediate structure

intermediate structure

intermediate structure

DCC, DMAP

CH2Cl2

RT, ON, 94%

intermediate structure

intermediate structure

DMAP, EDC.MeI

CH2Cl2

RT, 90 min, 98%

intermediate structure