Leimgruber-Batcho Indole Synthesis

Schematic representation of the Leimgruber-Batcho Indole Synthesis.
Mechanism of the Leimgruber-Batcho Indole Synthesis
Mechanism of the Leimgruber-Batcho Indole Synthesis
Sample reactions
intermediate structure
SiO2, Fe
AcOH, PhMe
Reflux, 20 min, 71%
intermediate structure
intermediate structure
H2, HCl, Pd/C
MeOH
62%
intermediate structure
intermediate structure
H2, Pd/C
AcOH, EtOAc, EtOH
RT, , 55%
intermediate structure