Grignard Reaction

Schematic representation of the Grignard Reaction.
Mechanism of the Grignard Reaction
Mechanism of the Grignard Reaction
Sample reactions
intermediate structure
MeMgBr
Et2O
-78 °C, 60 min, 63%
intermediate structure
intermediate structure
MeMgBr
THF
-20 °C, 2 h
intermediate structure
intermediate structure
MeMgBr
Et2O, PhH
0 °C to RT, 90 min
"The product depicted is the major component of an uncharacterized mixture of isomers."
intermediate structure
intermediate structure intermediate structure
Et2O, THF
-78 to -10 °C, 80 min
intermediate structure
intermediate structure intermediate structure
THF
-15 °C, 60 min, 68%
intermediate structure
intermediate structure
MeMgBr
Et2O, PhH
-18 °C, 3 h
intermediate structure
intermediate structure intermediate structure
Et2O, PhH
RT, 60 min
intermediate structure
intermediate structure
VinylMgBr
CH2Cl2, THF
-78 °C, 10 h, 76%
intermediate structure
intermediate structure
VinylMgBr
THF
0 °C, , 70% (2 steps)
intermediate structure
intermediate structure
IsopropenylMgBr
"No yield reported."
intermediate structure
intermediate structure
MeMgBr
CH2Cl2
-65 to -48 °C, 16.5 h, 95%
intermediate structure
intermediate structure
ZnCl2, AllylMgBr
THF
-78 °C, 17 min, 89%
intermediate structure
intermediate structure intermediate structure
t-BuMgCl
THF
-78 °C, 90 min, 68%
intermediate structure
intermediate structure
MeMgBr
Et2O
-78 °C, 100 min, 99%
intermediate structure
intermediate structure
MeMgBr
Et2O
0 °C, 60 min, 77%
intermediate structure
intermediate structure
MeCHO, Mg
Et2O
97%
intermediate structure
intermediate structure
VinylMgBr
THF
-78 °C, 2 h, 90%
intermediate structure
intermediate structure
MeMgI
Et2O
RT, 4.5 h
intermediate structure
intermediate structure
MeMgBr
Et2O
0 °C, 60 min, 87% (2 steps)
intermediate structure
intermediate structure
MeMgBr
THF
-78 °C, 3 h, 91%
intermediate structure
intermediate structure intermediate structure
EtMgBr
THF
0 °C to RT, 4 h, 69%
"The yield was 83 % brsm."
intermediate structure
intermediate structure
VinylMgBr
Et2O
0 °C, , 97%
intermediate structure
intermediate structure
EtMgBr
THF
RT, 48 h
intermediate structure
intermediate structure
ClCO2Me, Mg, Br(CH2)2Br
THF
RT to Reflux, 5 h, 98%
intermediate structure
intermediate structure
MeMgBr
intermediate structure
intermediate structure
VinylMgBr
THF
0 °C to RT, 3 h, 90% (2 steps)
intermediate structure
intermediate structure intermediate structure
Ac2O, DMAP, Mg
Et2O
79%
intermediate structure
intermediate structure
AllylMgCl
THF
-78 °C, 30 min, 85% (2 steps)
intermediate structure
intermediate structure
(CH2O)n, i-PrMgBr
THF
45 °C, 5.5 h, 89% (α), 78 % (β)
intermediate structure
intermediate structure
VinylMgBr
Et2O
-30 °C to RT, 10 min, 56%
intermediate structure
intermediate structure
MeMgI
Et2O
Reflux, 60 min
intermediate structure
intermediate structure
VinylMgBr
THF
10 °C to RT, 4.5 h, 46% (2 steps)
intermediate structure
intermediate structure
VinylMgBr
THF
0 °C, 3 h, 76%
intermediate structure
intermediate structure intermediate structure
THF
0 °C, 4 h
intermediate structure