Dieckmann Condensation

Mechanism of the Dieckmann Condensation

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Reviews |
Sample reactions

NaOMe
MeOH
Reflux, 20 min, 88%


i-Pr2NLi
THF
-78 °C, 40 min, 84%


KOt-Bu
Et2O
0 °C, 3 h



i-Pr2NLi
THF
-78 °C to RT, 3 h, 64-85%


TBSCl, TMS2NLi
Hexane(s), HMPA, THF
Reflux, 2.5 h


NaH
MeOH, PhMe
Reflux


NaOMe
PhMe
Reflux, , 33%


NaH, (CO2Me)2
DMF, MeOH
35-80 °C, , 44%


NaH
DMF, MeOH
RT to 155 °C, 20 min


H2O, HCl, KOt-Bu
PhMe, t-BuOH
0 °C to Reflux, ON, 100%
