Aldol Condensation

Schematic representation of the Aldol Condensation.
Mechanism of the Aldol Condensation
Mechanism of the Aldol Condensation
Sample reactions
intermediate structure intermediate structure
CuI, MeLi
THF
0 °C to RT, 45 min, 60%
intermediate structure
intermediate structure
KOt-Bu
THF
Reflux, 6 h, 75%
intermediate structure
intermediate structure
NaOMe
MeOH
-10 °C, 10 min, 69%
intermediate structure
intermediate structure
NaOH
H2O, MeOH
Reflux, 2 h, 58% (2 steps)
intermediate structure
intermediate structure
AcOH, Piperidine
PhH
60 °C, 60 min, 66% (2 steps)
intermediate structure
intermediate structure
Pyrrolidinium acetate
MeOH
intermediate structure
intermediate structure
KOH
EtOH
Reflux, , 84%
intermediate structure
intermediate structure
NaOH
H2O, THF
RT, 10 h, 70% (3 steps)
intermediate structure
intermediate structure
TiCl4
o-Dichlorobenzene
85%
intermediate structure
intermediate structure
NaOt-Amyl
PhH
Reflux, 3.5 h, 89%
intermediate structure
intermediate structure
NaH
PhMe
Reflux, 18.5 h, 66%
intermediate structure
intermediate structure
Al2O3
CH2Cl2
RT, 2 h, 70%
intermediate structure
intermediate structure
KOt-Bu
t-BuOH
0 °C, 60 min
intermediate structure
intermediate structure
KOH
EtOH, H2O
55 °C, 90 min, 40%
intermediate structure
intermediate structure
KOH, n-Bu4N+ OH-
Et2O, THF
Reflux, ON, 97%
intermediate structure
intermediate structure intermediate structure
NaOMe
MeOH, THF
-10 to 2 °C, 18 h, 90%
intermediate structure
intermediate structure intermediate structure
KOH
MeOH
RT, 30 min, 85%
intermediate structure
intermediate structure
Me3N+Bn HO-, MeCN
PhH
Reflux, 2 h, 82%
intermediate structure
intermediate structure
KOH, n-Bu4N+ OH-
Et2O, H2O, THF
Reflux, 4 h, 84% (2 steps)
intermediate structure
intermediate structure intermediate structure
KOH
H2O
95 °C, 6 h
intermediate structure