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Eurystatin A

"Dedicated to the memory of Joseph E. Semple."

Chemical structure of Eurystatin_A
C23H38N4O5
Author J. Edward Semple
Publication year 2001
Synthesis type Total synthesis
Number of steps 9 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
CH3CO2CHO
Et3N
0 °C to RT, 90%
Chemical structure
ClCO2CCl3, N-Methylmorpholine
CH2Cl2
-40 to -15 °C, 98%
Chemical structure + Chemical structure
+
Chemical structure
CH2Cl2
0 °C to RT, 4 d, 80%

See the Passerini Reaction
Chemical structure
Et2NH
CH2Cl2
RT, ON, 75%
Chemical structure
H2, Pd/C
MeOH
95%
Chemical structure
(PhO)2P(O)N3, NaHCO3
DMF
0-4 °C, 5 d, 85%
Chemical structure
HCl
EtOAc
0 °C to RT, 100%
Chemical structure + Chemical structure
EDC, HOAt
DMF
RT, 93%
Chemical structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
5 °C to RT, 75%

See the Parikh-Doering Oxidation
Chemical structure

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