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Named reactions

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Search synthesis

Indolizidine 223A

Chemical structure of Indolizidine_223A
C15H29N
Author Dawei Ma
Publication year 2005
Synthesis type Total synthesis
Number of steps 11 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
+
Chemical structure
n-BuLi
THF
-78 °C to RT, 6 h, 67%

Selectivity : 99:01 dr
See the Michael Addition
Chemical structure
LiAlH4
THF
Reflux, 12 h, 90%
Chemical structure
SOCl2
CHCl3
0 °C to Reflux, 60 min
Chemical structure
H2, Pd(OH)2/C
50 atm
MeOH
40 °C, 48 h, 90% (2 steps)
Chemical structure + Chemical structure
K2CO3
4 Å MS
MeCN
Reflux, 80%
Chemical structure
H2, PtO2
1 atm
AcOH
RT, 2 h
Chemical structure
NaOEt
EtOH
Reflux, 5 h, 81% (2 steps)
Chemical structure
LiAlH4
THF
RT, 60 min, 91%
Chemical structure
(COCl)2, DMSO, Et3N
CH2Cl2
-78 °C to RT, 35 min

See the Swern Oxidation
Chemical structure
Ph3P+CH3 I-, TMS2NNa
THF
-78 to 0 °C, 90 min

See the Wittig Reaction
Chemical structure
H2, Pd/C
EtOAc
RT, 2 h, 49% (3 steps)
Chemical structure

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