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Named reactions

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Search synthesis

Lysergic Acid

Chemical structure of Lysergic_Acid
C16H16N2O2
Author Robert B. Woodward
Publication year 1954
Synthesis type Total synthesis
Number of steps 14 (linear)
References

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
H2, Ni (Raney), NaOH
200-270 atm
H2O
RT, 20-30 h
Chemical structure
BzCl, NaOH
H2O
RT to 40 °C, 70% (2 steps)

See the Schotten-Baumann Reaction
Chemical structure
SOCl2
RT to reflux, 45-55 min
Chemical structure
AlCl3
CS2
Reflux, 60 min, 77% (2 steps)

See the Friedel-Crafts Acylation
Chemical structure
PyrHBr3
hv
AcOH
40-60 °C, 30 min, 69%
Chemical structure + Chemical structure
PhH
Reflux, 21 h, 71%
Chemical structure
HCl
H2O
37 °C, 5 d, 77%
Chemical structure
NaOMe
MeOH
-10 °C, 10 min, 69%

See the Aldol Condensation
Chemical structure
Ac2O
RT, 5 min, 82%
Chemical structure
  1. NaBH4
  2. HCl
MeOH, H2O
RT, 2 h, 79%
Chemical structure
SOCl2
SO2
RT, 6 h
Chemical structure
NaCN, HCN
0-10 °C, 30 min, 54% (2 steps)
Chemical structure
H2SO4
MeOH, H2O
100 °C, 24 h, 53%
Chemical structure
  1. KOH
  2. Ni (Raney), Na3AsO4.12H2O
H2O
Reflux, 20.5 h, 30%
Chemical structure

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