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Named reactions

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Search synthesis

Cocaine

Chemical structure of Cocaine
C17H21NO4
Author Joseph J. Tufariello
Publication year 1978
Synthesis type Total synthesis
Number of steps 9 (linear)
References

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
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Chemical structure
HgO
PhMe
Reflux, 15 h, 96%

See the Huisgen Cycloaddition
Chemical structure
mCPBA
CH2Cl2
0 °C to RT, 2 h
Chemical structure
Methyl acrylate
PhMe
Reflux, 20 h, 77% (2 steps)
Chemical structure
MsCl
Pyr
0 °C to RT, 4 h, 95%
Chemical structure
DBN
PhH
RT, 4 h, 86%
Chemical structure
Xylene(s)
Reflux, 3 h

See the Huisgen Cycloaddition
Chemical structure
MeI
CH2Cl2, Et2O
RT, 12 h, 58%
Chemical structure
Zn
AcOH, H2O
70 °C, 3.5 h, 47%
Chemical structure
BzCl, Na2CO3
PhH
Reflux, 10 h, 37%
Chemical structure

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