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Named reactions

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Search synthesis

Alkaloid 251F

Chemical structure of Alkaloid_251F
C16H29NO
Author Jeffrey Aubé
Publication year 2002
Synthesis type Total synthesis
Number of steps 10 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
NHMeOMe.HCl, BOP reagent
CH2Cl2, Et3N
RT, 24.5 h, 95%
Chemical structure
VinylMgBr
THF
0 °C, 60 min, 95%

See the Weinreb Ketone Synthesis
Chemical structure
Grubbs catalyst (1st gen.), C2H4
1 atm
CH2Cl2
RT, 12 h, 93%

See the Olefin Metathesis
Chemical structure + Chemical structure
MeLi, CuI
THF
0 °C to RT, 45 min, 60%

See the Michael Addition
See the Aldol Condensation
Chemical structure
Na
NH3, THF, EtOH
-78 °C, 10 min, 54%

Selectivity : 80:20 R/S
See the Birch Reduction
Chemical structure
Zn(N3)2.2Pyr, DEAD, Ph3P
RT, 12 h, 100%

Selectivity : 80:20 R/S
See the Mitsunobu Reaction
Chemical structure
  1. O3
  2. Me2S
CH2Cl2
-78 °C to RT, 24 h, 70%

Selectivity : 80:20 R/S
Chemical structure
NaBH4
EtOH
0 °C, 78%
Chemical structure
TfOH
CH2Cl2
0 °C, 6 h, 79%

See the Schmidt Reaction
Chemical structure
LiAlH4
Et2O
0 °C, 20 min, 86%
Chemical structure

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