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Named reactions

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Search synthesis

Acromelobinic Acid

Chemical structure of Acromelobinic_Acid
C9H10N2O5
Author Maciej Adamczyk
Publication year 2001
Synthesis type Total synthesis
Number of steps 10 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
mCPBA
CHCl3
RT, 15 h, 78 %
Chemical structure
Ac2O
Reflux, 3 h
Chemical structure
NaOMe
MeOH
0 & deg;C, 10 min, 60 % (2 steps)
Chemical structure
MeI, Ag2CO3
CHCl3
RT, 5 d, 93 %
Chemical structure
NBS, AIBN
CCl4
Reflux, 45 min, 77 %

See the Wohl-Ziegler Reaction
Chemical structure
HMTA
AcOH, H2O
Reflux, 60 min, 34 %

See the Sommelet Reaction
Chemical structure
+
Chemical structure
1,1,3,3-Tetramethylguanidine
THF
0 °C to RT, 6 h, 66 %

See the Horner-Wadsworth-Emmons Reaction
Also isolated was the E-isomer (10 % yield).
Chemical structure
Reagent structure
H2
2.5 atm
MeOH
RT, 93 %

Selectivity : 98:02 er
See the Noyori Asymmetric Hydrogenation
Chemical structure
LiOH
THF, H2O
RT, 60 min
Chemical structure
TMSI
CHCl3, MeOH
Reflux, 19 h, 88 % (2 steps)
Chemical structure

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