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Named reactions

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Clavukerin A

Chemical structure of Clavukerin_A
C12H18
Author Hans J. Schäfer
Publication year 2002
Synthesis type Formal synthesis
Number of steps 8 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
AcOOH, Na2CO3
CH2Cl2
RT, 24 h, 68%

See the Prilezhaev Reaction
Chemical structure
MeLi, CuCN
Et2O
-78 °C, 81%
Chemical structure
CrO3, H2SO4
CH2Cl2, H2O
0 °C, 60 min, 68%

See the Jones Oxidation
Chemical structure + Chemical structure
TiCl4
CH2Cl2
-78 °C, 60 min, 46%

See the Danheiser Annulation
Also isolated was the C8-epimer (46 % yield).
Chemical structure
K2CO3
MeOH
RT, 2 h
Chemical structure
n-Bu4N+ F-
MeOH
78% (2 steps)
Chemical structure

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Remaining...
73% (2 steps)

See : J. Org. Chem. 1991, 56, 6829.
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