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Search synthesis

L-163007

Chemical structure of L-163007
C34H38F3N5O6S
Author Linda L. Chang
Publication year 1994
Synthesis type Total synthesis
Number of steps 10 (3 parts)
References

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Part 1 of 3
Chemical structure
+
Chemical structure
Et3N
PhMe
50 to 95 °C, ON, 58%
Chemical structure

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Part 2 of 3
Chemical structure
t-BuNH2
CHCl3
RT, 12 h, 84%
Chemical structure + Chemical structure
Pd(PPh3)2Cl2
DMF
90 °C, 5 h, 74%

See the Stille Coupling
Chemical structure
NBS, AIBN
CCl4
Reflux, 3 h, 78%

See the Wohl-Ziegler Reaction
Chemical structure

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Part 3 of 3
Chemical structure
+
Chemical structure
NaH
DMF
50 °C, 4 h, 92%
Chemical structure
ClF2CCO2Me, KF, CuI
DMF
120 °C, 12 h, 37%
Chemical structure
H2, PtO2
4 atm
EtOAc, EtOH
RT, 100%
Chemical structure
EtCOBr, DMAP
Pyr
RT, ON, 90%
Chemical structure
PhOMe
CF3CH2OH
RT, ON, 91%
Chemical structure
Boc2O, NaH
THF
50 °C, 22 h, 74%
Chemical structure

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