Synthesis of Nupharamine
C15H25NO2
Principal investigator | Franklin A. Davis |
---|---|
Publication year | 2006 |
Synthesis type | Formal |
Number of steps | 8 (linear) |
References |
Part 1 of 1
+
+
Ti(OEt)4
CH2Cl2
RT, 5 h, 92%
CF3CO2H
MeOH
0 °C, 2 h
MgSO4
CH2Cl2
RT, 2 h, 86% (2 steps)
BF3.OEt2,
(CH2SH)2
CH2Cl2
0 °C to RT, 2 h, 93%
Ni (Raney)
EtOH
Reflux, 2 h, 78%
Remaining...
(3 steps)
"See: J. Org. Chem. 1999, 64, 3736."