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Named reactions

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Search synthesis

Strychnine

Chemical structure of Strychnine
C21H22N2O2
Author Stephen F. Martin
Publication year 2001
Synthesis type Formal synthesis
Number of steps 15 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
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Chemical structure
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Chemical structure
THF
-78 °C to RT, 2 h, 79%

See the Mannich Reaction
Chemical structure
Sealed tube
Mesitylene
160 °C, 72 h, 85%

See the Diels-Alder Reaction
Chemical structure
HClO4
THF, H2O
80 °C, 12 h, 93%
Chemical structure
Reagent structure
(Ph3P)3RuCl2
PhMe
Reflux, 24 h, 79%
Chemical structure
H2, Pd(OH)2/C
1 atm
EtOAc, EtOH
RT, 5 h, 67%
Chemical structure
NaOMe, TsOH
MeOH
0 °C to RT, 30 h, 74%
Chemical structure
TBSCl, DMAP
Pyr
RT, 24 h, 71%
Chemical structure
Me3O+ BF4-, 2,6-Di-tert-butylpyridine
MeOH
RT, 24.5 h, 83%
Chemical structure
t-BuOCl, SnCl4
PhMe
-15 °C, 60 min
Chemical structure
TMS2NLi
THF
-15 °C to RT, 3.5 h, 26%

See the Mannich Reaction
Chemical structure
HCl
MeOH, H2O
RT, ON, 83%
Chemical structure

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Remaining...
34% (4 steps)

See: J. Am. Chem. Soc. 1993, 115, 9293.
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