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Named reactions

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Epibatidine

Chemical structure of Epibatidine
C11H13ClN2
Author Andrew C. Regan
Publication year 1993
Synthesis type Total synthesis
Number of steps 7 (3 parts)
Reference

Browse hundreds of other total syntheses.

Part 1 of 3
Chemical structure
+
Chemical structure
80-85 °C, 24 h, 36%

See the Diels-Alder Reaction
Chemical structure
H2, Pd/C
MeCN
RT, 99%
Chemical structure
Na(Hg), Na2HPO4, NaH2PO4
MeOH, THF
-78 °C to RT

No yield given.
Chemical structure

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Part 2 of 3
Chemical structure
I2, HIO4, H2SO4
AcOH, H2O
80 °C, 53%
Chemical structure
NaNO2, HCl
H2O
0 °C to RT, 74%

See the Sandmeyer Reaction
Chemical structure

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Part 3 of 3
Chemical structure
+
Chemical structure
Pd(OAc)2, Ph3P, Piperidine, HCO2H
DMF
70 °C, 6.5 h, 35%

See the Heck Coupling
Chemical structure
HBr
AcOH
RT, 22 h, 74%
Chemical structure

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