Synarchive logo
Google+ Facebook Twitter RSS Feed
Support this website
Synarchive is free but requires a lot of work. If you enjoy and find it useful, please support us by making a donation.
Named reactions

Get references and more from over 229 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

Go to the protecting groups index

Search synthesis

Strychnine

Chemical structure of Strychnine
C21H22N2O2
Author Joan Bosch
Publication year 2000
Synthesis type Total synthesis
Number of steps 14 (linear)
References

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
O3
CH2Cl2
-78 °C, 3 h
Chemical structure + Chemical structure
NaBH3CN
i-PrOH
RT, 2 d, 37% (2 steps)
Chemical structure
ClCO2CH(Cl)CH3
135 °C, 2 d, 72%
Chemical structure
TMSI, TMS2NH
CH2Cl2, Pentane
-20 °C, 6 h, 100%
Chemical structure
PhSeCl, (PhSe)2
THF
-35 °C to RT, 4.5 h, 70%
Chemical structure
O3, i-Pr2NH
CH2Cl2
-78 °C to RT, 72%
Chemical structure
MeOH
Reflux, 3 h, 100%
Chemical structure + Chemical structure
K2CO3, LiI
MeCN
50 °C, 3 h, 74%
Chemical structure
Pd(OAc)2, Ph3P
Et3N
90 °C, 90 min, 53%

See the Heck Coupling
Chemical structure
MeO2CCN, TMS2NLi
THF, HMPA
-78 °C to RT, 4.5 h, 62%

The yield was 67 % brsm.
Chemical structure
Zn, H2SO4
MeOH
Reflux, 2 h, 36%
Chemical structure
NaOMe
MeOH
Reflux, 5 h, 72%
Chemical structure
i-Bu2AlH
PhMe
-40 °C, 25 min
Chemical structure
Malonic Acid, NaOAc
AcOH, Ac2O
110 °C, 2 h, 49% (2 steps)

See the Aldol Addition
Chemical structure

Report an error in this part

comments powered by Disqus
homepage - authors - molecules - named reactions - protecting groups - advanced search - contact
© 2011-2017 SynArchive