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Named reactions

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Search synthesis

Morphine

Chemical structure of Morphine
C17H19NO3
Author Kenner C. Rice
Publication year 1980
Synthesis type Total synthesis
Number of steps 18 (linear)
References

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
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Chemical structure
200 °C, 2 h, 95%
Chemical structure
POCl3
MeCN
Reflux, 70 min

See the Bischler-Napieralski Reaction
Chemical structure
NaBH3CN
MeOH, H2O
Reflux, 90 min, 86% (2 steps)
Chemical structure
Li
NH3, THF, t-BuOH
-75 to -55 °C, 5.5 h, 90%

See the Birch Reduction
Chemical structure
HCO2Ph
EtOAc
Reflux, 45 min, 94%
Chemical structure
MsOH, (CH2OH)2
THF
RT, 60 min
Chemical structure
N-Bromoacetamide
THF
0-5 °C, 30 min
Chemical structure
HCO2H
H2O
RT, 60 min, 90% (3 steps)
Chemical structure
NH4F, HF, TfOH
H2O
0 °C, 72-96 h, 60%
Chemical structure
HCl
MeOH, H2O
Reflux, 18 h, 98%
Chemical structure
Br2
AcOH
RT, 2 h
Chemical structure
NaOH
CHCl3, H2O
0 °C
Chemical structure
CH2O, H2, Pd/C, NaOAc
AcOH, H2O
79% (3 steps)
Chemical structure
ClCO2Me
PhH
Reflux, 16 h, 100%
Chemical structure
PhSeCl, HCl
EtOAc, H2O
RT, 4.5 h, 85%
Chemical structure
NaIO4
EtOAc, H2O
RT, 20 h, 68%
Chemical structure
LiAlH4
THF
Reflux, 71%
Chemical structure
BBr3
CHCl3
RT, 17 min, 91%
Chemical structure

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