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Named reactions

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Search synthesis

Oseltamivir

Chemical structure of Oseltamivir
C16H28N2O4
Author Barry M. Trost
Publication year 2008
Synthesis type Total synthesis
Number of steps 9 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
Reagent structure
3-C3H3PdCl)2, Trimethylsilylphthalimide
THF
40 °C, 8.5 h

Selectivity : 99:01 er
See the Trost Asymmetic Allylation Alkylation
Chemical structure
TsOH
EtOH
Reflux, 10 h, 84% (2 steps)

See the Fischer Esterification
Chemical structure
TMS2NK, PhSSO2Ph
THF
-78 °C to RT, ON, 94%
Chemical structure
mCPBA, NaHCO3, DBU
PhMe
0 to 60 °C, 7 h, 85%
Chemical structure
TMS(CH2)2SO2NH2, PhI(OPiv)2, Rh2(esp)2, MgO
PhCl
0 °C to RT, 4 h, 86%
Chemical structure
3-Pentanol, BF3.OEt2
75 °C, 15 min, 65%
Chemical structure
Ac2O, DMAP
µW
Pyr
150 °C, 60 min, 84%
Chemical structure
n-Bu4N+ F-
THF
RT, 30 min, 95%
Chemical structure
NH2NH2
EtOH
68 °C, 10 h, 100%
Chemical structure

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