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Named reactions

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Protecting Groups

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Search synthesis

Oseltamivir

Chemical structure of Oseltamivir
C16H28N2O4
Author Yujiro Hayashi
Publication year 2009
Synthesis type Total synthesis
Number of steps 8 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
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Chemical structure
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Chemical structure
Reagent structure
ClCH2CO2H
CH2Cl2
0 °C to RT, 3.5 h

Selectivity : 83:17 R/S
See the Michael Addition
Chemical structure
p-MePhSH
EtOH
-15 °C, 36 h, 70% (2 steps)

Selectivity : 98:02 er
See the Michael Addition
Chemical structure
CF3CO2H
CH2Cl2
RT, 2 h
Chemical structure
(COCl)2, DMF
CH2Cl2
0 °C to RT, 60 min
Chemical structure
NaN3
Acetone, H2O
0 °C, 20 min
Chemical structure
Ac2O
AcOH
RT, 49 h

See the Curtius Rearrangement
Chemical structure
Zn, TMSCl
EtOH
70 °C, 2 h
Chemical structure
NH3, K2CO3
EtOH
0 °C to RT, 6 h, 82% (6 steps)
Chemical structure

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