Synarchive logo
Google+ Facebook Twitter RSS Feed
Support this website
Synarchive is free but requires a lot of work. If you enjoy and find it useful, please support us by making a donation.
Named reactions

Get references and more from over 229 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

Go to the protecting groups index

Search synthesis

Quadrone

Chemical structure of Quadrone
C15H20O3
Author Eiichi Yoshii
Publication year 1983
Synthesis type Formal synthesis
Number of steps 15 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
+
Chemical structure
CH2Cl2
-78 °C, 7 h, 67%
Chemical structure
  1. i-Pr2NLi
  2. TMSCl
THF
-78 °C to RT, 90 min, 98%
Chemical structure
MeOCH2Cl, CH2I2, Zn-Cu
CH2Cl2
0 °C to RT, 4.5 h, 60%
Chemical structure
Propargyl bromide, Al, HgCl2
THF, Et2O
-78 to -40 °C, 90 min, 50%
Chemical structure
HCO2H
RT, 40 h
Chemical structure
HCrO3Cl.Pyr
CH2Cl2
RT, 10 h, 31% (2 steps)
Chemical structure
HgO, H2SO4
MeOH, H2O
60 °C, 60 min, 100%

See the Kucherov Reaction
Chemical structure
NaOt-Amyl
PhH
Reflux, 3.5 h, 89%

See the Aldol Condensation
Chemical structure
BBr3
CH2Cl2
-78 to -20 °C, 24 h
Chemical structure
CrO3, H2SO4
Acetone, H2O
RT, 30 min, 49% (2 steps)

See the Jones Oxidation
Chemical structure

Report an error in this part

Remaining...
24% (5 steps)

See : J. Am. Chem. Soc. 1981, 103, 4136.
comments powered by Disqus
homepage - authors - molecules - named reactions - protecting groups - advanced search - contact
© 2011-2017 SynArchive