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Named reactions

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Search synthesis

Colchicine

Chemical structure of Colchicine
C22H25NO6
Author Martin G. Banwell
Publication year 1996
Synthesis type Total synthesis
Number of steps 15 (linear)
Reference

Browse hundreds of other total syntheses.

Part 1 of 1
Chemical structure
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Chemical structure
NaOH
MeOH
RT, 48 h, 96%

See the Claisen-Schmidt Condensation
Chemical structure
H2, Pd/C
EtOAc
RT, 10 h, 96%
Chemical structure
NaBH4
THF
RT, 90 min, 96%
Chemical structure
Pb(OAc)4
3 Å MS
CH2Cl2
RT, 60 min, 100%
Chemical structure
CF3CO2H
3 Å MS
THF, PhH
0 °C, 60 min, 42%
Chemical structure
BnBr, K2CO3
MeCN
82 °C, 4 h, 88%
Chemical structure
n-Pr4N+ RuO4-, NMO
4 Å MS
CH2Cl2
RT, 43 h, 98%

See the Ley-Griffith Oxidation
Chemical structure
CBS Reagent
THF
RT, 6 h, 88%

Selectivity : 97:03
See the Corey-Itsuno Reaction
Chemical structure
H2, Pd/C
EtOAc
RT, 9 h, 99%
Chemical structure
Tl(NO3)3
MeOH
-20 °C, 30 min, 83%
Chemical structure
Me3SO+ I-, NaH
DMSO
RT, 7 h, 54%

See the Johnson-Corey-Chaykovsky Reaction
Chemical structure
CF3CO2H
CH2Cl2
RT, 3 h, 48%
Chemical structure
Zn(N3)2.2Pyr, DIAD, Ph3P
THF
RT, 38 h, 30%

See the Mitsunobu Reaction
Chemical structure
Ph3P
THF, H2O
RT, 2.5 d

See the Staudinger Reaction
Chemical structure
Ac2O
Pyr
RT, 15 min, 60% (2 steps)
Chemical structure

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