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Longifolene
| Author | Alex G. Fallis |
|---|---|
| Publication year | 1990 |
| Synthesis type | Total synthesis |
| Number of steps | 17 (linear) |
| References |
Browse hundreds of other total syntheses.
Part 1 of 1
+ 
Pyrrolidine
MeOH
0 °C to RT, 4 h, 86 %
0 °C to RT, 4 h, 86 %
MeLi
THF
-78 to 0 °C, 10 min, 65 %
-78 to 0 °C, 10 min, 65 %
+ 
COCl2
PhMe
0 °C
No yield reported.
0 °C
No yield reported.
LiAlH4
No yield reported.
No yield reported.
MnO2
81 %
+ 
BF3.OEt2
MeOH
RT, 4 h, 83 %
RT, 4 h, 83 %
H2, Pd/C
2 atm
EtOAc
RT, 4 h, 99 %
2 atm
RT, 4 h, 99 %
LiAlH4
Et2O
0 °C to RT, 4 h, 95 %
0 °C to RT, 4 h, 95 %
Ac2O, Pyr
Et2O
0 °C, 6 h, 74 %
0 °C, 6 h, 74 %
PhOC(S)Cl, Pyr
CH2Cl2
RT
RT
NaI, TMSCl, Et3N
CH2Cl2
RT, 60 min
RT, 60 min
PhOC(S)Cl, Pyr
CH2Cl2
RT
RT
Flow system
PhH
525 °C, 56 %
525 °C, 56 %
