Synthesis of Prismane

Structure of Prismane

C6H6

Principal investigator	Thomas J. Katz
Publication year	1973
Synthesis type	Total
Number of steps	5 (linear)
References	J. Am. Chem. Soc. 1973, 95, 2738. J. Am. Chem. Soc. 1971, 93, 3782.

Part 1 of 1

intermediate structure

MeLi, CH2Cl2

Et2O

-45 °C, 45%

intermediate structure

+

intermediate structure

Dioxane , Et2O

0 °C to RT, 60 min, 50-60%

intermediate structure

KOH

H2O, MeOH

Reflux, 24 h

intermediate structure

HCl, CuCl2

H2O

65% (2 steps)

intermediate structure

hν

PhMe

30 °C, 5 h, 8%

intermediate structure

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