The famous Rabe-Kindler quinine synthesis was repeated in 2008. The experimental details given were gathered from the 2008 article.
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RT, 24 h, 55 %
The starting material (quinotoxine) was obtained from the degradation of natural quinine.
Reflux, 10 min, 88 %
Selectivity : 50:50
See the Hofmann-Löffler-Freytag Reaction
Reflux, 2 h, 5 %
See the Meerwein-Ponndorf-Verley Reduction
Quinine was selectively cristallized (as a tartrate salt) from the resulting four diastereoisomers.