Triisopropylsilyl ether (TIPS)

Triisopropylsilyl ether (TIPS) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • TIPSCl Imidazole
    DMF
    0 °C - RT
    2 h
    98 %
    intermediate structure
    TIPSCl, Imidazole
    DMF
    0 °C to RT, 2 h, 98%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • n-Bu4N+ F-
    THF
    0 °C
    15 min
    98 %
    intermediate structure
    n-Bu4N+ F-
    THF
    0 °C, 15 min, 98%
    intermediate structure