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Named reactions

Get references and more from over 225 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Methyl ether

Protection

 
Reagents
Solvents
Temperature
Time
Yield
Me2SO4, KOH
MeOH, H2O
Reflux
90 min
90 %
Me3O+ BF4-, Proton Sponge ®
CH2Cl2
RT
12 h
85 %
Me2SO4, K2CO3, NaHSO3
Acetone
RT
3 h
82-86 %
Me2SO4, KOH
Acetone
RT
15 h
97 %
Me2SO4, K2CO3
Acetone
Reflux
2-16 h
90-96 %
MeI, NaOH, n-Bu4N+ Br-
H2O
Reflux
30 min
80 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
BBr3
CH2Cl2
-78 °C - RT
50 min - 24 h
78-90 %
Pyr.HCl
220 °C
6 min
34 %
BBr3
CHCl3
RT
17 min
91 %
BCl3
CH2Cl2
0 °C
15 min
90 %
NaSEt
DMF
150 °C
16 h
70 %
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