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Named reactions

Get references and more from over 225 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Benzyl ether (Bn)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
BnBr, K2CO3
MeCN
82 °C
4 h
88 %
BnBr, K2CO3, n-Bu4N+ I-
DMF
RT
6 h
93 %
BnBr, Ag2O
CH2Cl2
RT
18 h
92 %
BnBr, K2CO3
Acetone
RT - Reflux
2 - 6 h
92 - 95 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
H2, Pd/C
EtOAc, AcOH
RT
3 h
99 %
H2, Pd/C
EtOAc
RT
9 h
99 %
HBr
CH2Cl2
0 °C
2 h
80 %
Ni (Raney)
EtOH
Reflux
5 h
93 %
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