1-Chloroethyl carbamate (ACE)

1-Chloroethyl carbamate (ACE) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • n-BuLi ClCO2CH(Cl)CH3
    THF
    -78 °C to RT
    45 min
    89%
    info
    intermediate structure
    n-BuLi, ClCO2CH(Cl)CH3
    THF
    -78 °C to RT, 45 min, 89%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • K2CO3
    MeOH
    80 °C
    15 min
    65%
    info
    intermediate structure
    K2CO3
    MeOH
    80 °C, 15 min, 65%
    intermediate structure