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Named reactions

Get references and more from over 229 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Methyl ester

Protection

 
Reagents
Solvents
Temperature
Time
Yield
CH2N2
Et2O
RT
1 min - 3 h
92-100 %
CH2N2
MeOH
RT
60 min
84 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
LiOH
THF, H2O
0 °C - RT
60 min - 20 h
75 - 100 %
LiOH
THF, MeOH
RT
ON
97 %
NaOH
MeOH, H2O
RT - Reflux
4 - 17 h
99 %
KOH
MeOH, H2O
RT - 90 °C
60 min - 48 h
98-100 %
KOH
MeOH
Reflux
90 min
100 %
KOH
EtOH, H2O
RT - Reflux
6 - 20 h
91-100 %
MeSnOH
DCE
75 °C
48 h
78 %
NaOH
THF, H2O
5 °C
ON
96 %
KOH
Ethylene Glycol, H2O
140 °C
2 h
84 %
LiOH
MeCN, H2O
70 °C
4 h
73 %
LiOH
MeOH, H2O
RT
5 h
95 %
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