Benzyloxy carbamate (CBz)

Benzyloxy carbamate (CBz) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • ClCO2Bn Na2CO3
    THF
    RT
    ON
    96 %
    intermediate structure
    ClCO2Bn, Na2CO3
    THF
    RT, ON, 96%
    intermediate structure
  • ClCO2Bn K2CO3
    MeCN
    RT
    4 h
    99 %
    intermediate structure
    ClCO2Bn, K2CO3
    MeCN
    RT, 4 h, 99%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • H2 Pd(OH)2
    MeOH
    RT
    3 h
    95 %
    intermediate structure
    H2, Pd(OH)2
    MeOH
    RT, 3 h, 95%
    intermediate structure
    intermediate structure
    H2, Pd(OH)2
    MeOH
    RT, 3 h, 95%
    intermediate structure
  • Pd HCO2NH4
    MeOH
    RT
    14 h
    99 %
    intermediate structure
    Pd, HCO2NH4
    MeOH
    RT, 14 h, 99%
    intermediate structure
  • H2 Pd/C
    MeOH
    RT
    4 h
    100 %
    intermediate structure
    H2, Pd/C
    MeOH
    RT, 4 h, 100%
    intermediate structure