Neopentyl glycol acetal

Neopentyl glycol acetal scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • Neopentyl glycol Camphorsulfonic acid
    PhH
    Reflux
    6 h
    96 %
    intermediate structure
    Neopentyl glycol, Camphorsulfonic acid
    PhH
    Reflux, 6 h, 96%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • HCl
    MeOH
    0 °C - RT
    2 h
    96 %
    intermediate structure
    HCl
    MeOH
    0 °C to RT, 2 h, 96%
    "Both C1-epimers were separated and the following steps were carried in separate vessels."
    intermediate structure