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Named reactions

Get references and more from over 225 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Ethylene glycol acetal

Protection

 
Reagents
Solvents
Temperature
Time
Yield
(CH2OH)2, TsOH
PhMe
Reflux
4 h
93 %
(TMSOCH2)2, TMSOTf
CH2Cl2
-78 - -15 °C
90 min
99 %
(CH2OH)2, Dowex 50WX8 ®
PhH
Reflux
30 h
90 %
(CH2OH)2, TsOH
PhH
Reflux
6 h
95 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
HCl
EtOH, H2O
RT
4 h
100 %
TsOH
Acetone, H2O
Reflux
15 min - 2.5 h
84-97 %
Pyr.TsOH
Acetone, H2O
RT
24 h
98 %
Ph3C+ BF4-
CH2Cl2
RT
2 h
92 %
Camphorsulfonic acid
Acetone
RT
2 d
62 %
H2SO4
RT
30.5 h
92 %
TsOH
THF, MeOH, H2O
RT
60 min
90 %
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