1,3-Dithiane

1,3-Dithiane scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • HS(CH2)3SH BF3.OEt2
    CH2Cl2
    RT
    60 min
    78 %
    intermediate structure
    HS(CH2)3SH, BF3.OEt2
    CH2Cl2
    RT, 60 min, 78%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • MeI CaCO3
    MeCN H2O
    RT - 55 °C
    10 h - 4 d
    84-98 %
    intermediate structure
    MeI, CaCO3
    MeCN, H2O
    55 °C, 10 h, 98%
    intermediate structure
    intermediate structure
    MeI, CaCO3
    MeCN, H2O
    RT, 4 d, 84%
    intermediate structure